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In a cogitation of intelligent Male volunteers, Viagra (100 mg) did non move the unfaltering province pharmacokinetics of the Human immunodeficiency virus proteolytic enzyme inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. In healthy male volunteers, there was no manifest of a clinically substantial event of azithromycin (500 mg day-to-day for 3 days) on the systemic photograph of sildenafil citrate or its Major circulating metabolite. Thither was no issue on spermatozoon move or syllable structure later on ace 100 mg unwritten doses of Sildenafil in intelligent volunteers.
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