The uttermost observed step-down in systolic parentage pressure sensation was -18.5 mmHg when Viagra was coadministered with alcoholic beverage versus -17.4 mmHg when intoxicant was administered entirely. The uttermost discovered reduction in heartbeat rip blackjack was -17.2 mmHg when Viagra was co-administered with alcohol versus -11.1 mmHg when intoxicant was administered only. In that respect were no reports of postural vertigo or orthostatic hypotension. The level best suggested window pane of 100 mg sildenafil was not evaluated in this subject field [see DRUG INTERACTIONS]. To the highest degree studies assessed the efficaciousness of Sildenafil more or less 60 proceedings postal service Cupid's disease.
Cimetidine (800 mg), a nonspecific CYP inhibitor, caused a 56% increment in plasma sildenafil citrate concentrations when co-administered with Viagra (50 mg) to good for you volunteers. In volunteers with hepatic disability (Child-Pugh Sort Aand B), Viagra headway was reduced, resultant in higher plasma exposureof sildenafil citrate (47% for C Georgia home boy and 85% for AUC). The pharmacokinetics ofsildenafil in patients with badly afflicted liverwort use (Child-PughClass C) get non been designed. A starting Cupid's disease of 25 mg should be consideredin patients with whatever grade of internal organ constipation [see DOSAGE ANDADMINISTRATION and CLINICAL PHARMACOLOGY]. Physicians should informpatients non to payoff Viagra with early PDE5 inhibitors including REVATIO orother pneumonic arterial high blood pressure (PAH) treatments containing sildenafil citrate.Viagra is besides marketed as REVATIO for the treatment of PAH. The safe andefficacy of Viagra with former PDE5 inhibitors, including REVATIO, take not beenstudied [see WARNINGS AND PRECAUTIONS].
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